603 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study identifies syndecan-1 as a critical driver of alveolar type 2 epithelial cell senescence and impaired lung repair in pulmonary fibrosis, demonstrating that its age- and disease-associated upregulation disrupts epithelial regeneration while its genetic loss attenuates senescence and preserves function.
This study introduces the integrated CLEAP-scMAPS pipeline, a novel single-cell multi-omics platform that enables unbiased transcriptome-proteome co-profiling of rare cerebrospinal fluid circulating tumor cells, revealing that malignant dormancy and post-transcriptional buffering are key mechanisms driving chemotherapeutic resistance in leptomeningeal metastasis.
During Fc gamma receptor-mediated phagocytosis, the ER-resident phosphatase PTP1B localizes to actin-cleared membrane contact sites to dephosphorylate Syk and suppress the Syk-Shc1-NOX2 signaling axis, thereby limiting excessive superoxide production.
This study demonstrates that sustained exposure to the inflammatory secretome of activated CAR-T cells directly impairs human hematopoietic stem cell function through IFNγ and TNFα signaling, causing prolonged cytopenias that can be reversed by dual cytokine blockade without compromising antitumor efficacy.
This study reveals that Aurora kinase A (AURKA) and the mitophagy receptor PHB2 form a platform of inner mitochondrial membrane interactors with respiratory chain proteins to spatially regulate ATP production and organelle architecture, thereby driving metabolic heterogeneity in cancer cells.
This study demonstrates that the pharmacological NRF2 activator Omaveloxolone upregulates NRF2-target proteins and modestly increases SMN protein levels in Spinal Muscular Atrophy type I fibroblasts, which exhibit diminished basal NRF2 pathway output compared to controls.
This study establishes a reproducible, ISSCR-compliant protocol for generating and characterizing rhesus macaque induced pluripotent stem cells (RhiPSCs) from MAPT R406W mutation carriers, providing a critical resource for cross-species in vitro modeling of genetic frontotemporal dementia.
This paper introduces single-cell APEX-seq, a proximity labeling-based method that maps subcellular transcriptomes at single-cell resolution to reveal interaction-dependent cell states and identify regulators like CTSW that enhance CAR T cell persistence and tumor killing, which are often missed by conventional scRNA-seq.
This study identifies a rare Tcf4 lineage-negative stem cell population in the colon that is essential for wound repair and serves as the specific cell of origin for Apc-deletion-induced tumors in a Tcf4-haploinsufficient background.
This study identifies calcium-responsive centrin-Sfi1 protein networks as the molecular basis for the ultrafast, ATP-independent contraction in the giant ciliate *Spirostomum ambiguum*, demonstrating how their fishnet geometry and calcium-triggered compaction enable rapid whole-cell shortening through a mechanism distinct from traditional actomyosin systems.